Iliopoulou Dimitra, Vagias Constantinos, Galanakis Dimitrios, Argyropoulos Dimitris, Roussis Vassilios
Department of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, University of Athens, Panepistimioupolis Zografou, Greece.
Org Lett. 2002 Sep 19;4(19):3263-6. doi: 10.1021/ol026506z.
[structure: see text] Three novel halogenated rearranged sesquiterpenes (1-3) have been isolated along with brasilenol (4) and epibrasilenol (5) from the organic extract of the red alga Laurencia obtusa, collected at Symi island in the Aegean Sea, Greece. The new metabolites possess the unusual skeleton of brasilane and contain the unprecedented 1,6-epoxy moiety. The structures of the new natural products, as well as their relative stereochemistry, were established by means of spectral data analyses, including two-dimensional NMR experiments along with molecular calculations.
[结构：见正文] 从采集于希腊爱琴海希米岛的红藻钝形劳伦藻的有机提取物中，分离出了三种新型卤代重排倍半萜（1 - 3），以及巴西醇（4）和表巴西醇（5）。这些新的代谢产物具有不寻常的巴西烷骨架，并含有前所未有的1,6 - 环氧部分。通过光谱数据分析，包括二维核磁共振实验以及分子计算，确定了这些新天然产物的结构及其相对立体化学。
