Genome mining in J1-030: discovery and identification of novel sesquiterpene synthase and its products.

Sesquiterpene synthases in have been seldom studied, despite the efficiency of filamentous fungi for terpenoid production. Using the farnesyl diphosphate-overexpressing platform to produce diverse terpenoids, we herein identified an unknown sesquiterpene synthase from by genome mining and determined the structure of its corresponding products. One new 5/6 bicyclic sesquiterpene and its esterified derivative were characterised by GC-MS and 1D and 2D NMR spectroscopy. To the best of our knowledge, this is the first well-identified sesquiterpene synthase from to date.