两种爱琴海产的中新 C 型醋酸酯。

New C Acetogenins from Two Species of from the Aegean Sea.

机构信息

Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

出版信息

Molecules. 2022 Mar 13;27(6):1866. doi: 10.3390/molecules27061866.

DOI:10.3390/molecules27061866

PMID:35335229

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8953645/

Abstract

The chemical diversity of the approximately 1,200 natural products isolated from red algae of the genus , in combination with the wide range of their biological activities, have placed species of in the spotlight of marine chemists' attention for over 60 years. The chemical investigation of the organic (CHCl/MeOH) extracts of and , both collected off the coasts of Tinos island in the Aegean Sea, resulted in the isolation of 32 secondary metabolites, including 23 C acetogenins (-), 7 sesquiterpenes (-) and 2 diterpenes ( and ). Among them, six new C acetogenins, namely 10-acetyl-sagonenyne (), -sagonenyne (), -thuwalenyne C (), tinosallene A (), tinosallene B () and obtusallene XI (), were identified and their structures were elucidated by extensive analysis of their spectroscopic data. Compounds -, -, and - were evaluated for their antibacterial activity against and .

摘要

从红藻属中分离得到的约 1200 种天然产物具有丰富的化学多样性，其广泛的生物活性使得该属中的物种成为海洋化学家关注的焦点已有 60 多年。对采集自爱琴海蒂诺斯岛沿海的和的有机（CHCl/MeOH）提取物进行了化学研究，从中分离出了 32 种次生代谢产物，包括 23 种 C 型乙酰氧基酮（-）、7 种倍半萜（-）和 2 种二萜（和）。其中，鉴定出了 6 种新的 C 型乙酰氧基酮，分别为 10-乙酰-sagonenyne（）、-sagonenyne（）、-thuwalenyne C（）、tinosallene A（）、tinosallene B（）和 obtusallene XI（），通过对其光谱数据的广泛分析确定了它们的结构。对化合物 -、-、- 和 - 进行了抗菌活性评估，测试了它们对和的抑制效果。