来自红藻 Laurencia scoparia 的新型倍半萜衍生物。分离、结构测定及驱虫活性。

New sesquiterpene derivatives from the red alga Laurencia scoparia. Isolation, structure determination, and anthelmintic activity.

作者信息

Davyt D, Fernandez R, Suescun L, Mombrú A W, Saldaña J, Domínguez L, Coll J, Fujii M T, Manta E

机构信息

Cátedra de Química Farmacéutica, Facultad de Química, Universidad de la República, Avenida Gral. Flores 2124, Montevideo, Uruguay.

出版信息

J Nat Prod. 2001 Dec;64(12):1552-5. doi: 10.1021/np0102307.

DOI:10.1021/np0102307

PMID:11754610

Abstract

Eleven sesquiterpenes (1-11) and one long chain aldehyde (12) have been isolated from the dichloromethane extract of the red alga Laurencia scoparia. Four of them are new natural products. Scopariol (1) is a new natural product with an unusual rearranged chamigrane-type structure. The other three are beta-chamigrenes: isorigidol (2), (+)-3-(Z)-bromomethylidene-10 beta-bromo-beta-chamigrene (3), and (-)-3-(E)-bromomethylidene-10 beta-bromo-beta-chamigrene (4). The in vitro activity of compounds 1-12 against the parasitant stage of Nippostrongylus brasiliensis (L4) has been studied.

摘要

从红藻 Laurencia scoparia 的二氯甲烷提取物中分离出了 11 种倍半萜（1 - 11）和 1 种长链醛（12）。其中有 4 种是新的天然产物。Scopariol（1）是一种具有不寻常重排菖蒲烷型结构的新天然产物。另外 3 种是β-菖蒲烯类：异瑞吉醇（2）、（+）-3-（Z）-溴亚甲基-10β-溴-β-菖蒲烯（3）和（-）-3-（E）-溴亚甲基-10β-溴-β-菖蒲烯（4）。研究了化合物 1 - 12 对巴西日圆线虫（L4）寄生阶段的体外活性。