Kobayashi Jun'ichi, Shimbo Kazutaka, Sato Masaaki, Tsuda Masashi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
J Org Chem. 2002 Sep 20;67(19):6585-92. doi: 10.1021/jo016222c.
Six new macrolides, amphidinolides H2 (5), H3 (6), H4 (7), H5 (8), G2 (9), and G3 (10), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). Cytotoxicity of five derivatives (11-15) of amphidinolide H (1) in addition to 10 amphidinolides (1-10) containing amphidinolides H (1), G (2), B (3), and D (4) was examined, and it was found that the presence of an allyl epoxide, an S-cis-diene moiety, and the ketone at C-20 was important for the cytotoxicity of amphidinolide H (1)-type macrolides.
从海洋双鞭毛藻Amphidinium sp.（菌株Y - 42）中分离出了六种新的大环内酯类化合物，分别为两性霉素H2（5）、H3（6）、H4（7）、H5（8）、G2（9）和G3（10）。除了包含两性霉素H（1）、G（2）、B（3）和D（4）的10种两性霉素（1 - 10）外，还检测了两性霉素H（1）的五种衍生物（11 - 15）的细胞毒性，发现烯丙基环氧化物、S - 顺式二烯部分以及C - 20位的酮对于两性霉素H（1）型大环内酯类化合物的细胞毒性很重要。
