Bonnet Richard, Chanal Catherine, Ageron Elisabeth, Sirot Danielle, De Champs Christophe, Grimont Patrick, Sirot Jacques
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France.
Antimicrob Agents Chemother. 2002 Oct;46(10):3316-9. doi: 10.1128/AAC.46.10.3316-3319.2002.
Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence shares 69 to 72% identity with those of the other AmpC-type beta-lactamases of ENTEROBACTERIACEAE: This enzyme exhibits an atypical high affinity for all beta-lactams tested.
广泛的生化测试以及16S rRNA和rpoB序列分析表明,临床菌株CF01Ent1最初使用Api 32生化鉴定条被鉴定为阿氏布丘菌,实际上是肠杆菌科中的一种新生物。它产生一种可诱导的AmpC型β-内酰胺酶,其序列与肠杆菌科其他AmpC型β-内酰胺酶的序列具有69%至72%的同源性:该酶对所有测试的β-内酰胺类药物均表现出非典型的高亲和力。