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Linezolid Resistance Genes and Mutations among Linezolid-Susceptible spp.-A Loose Cannon?利奈唑胺敏感菌中的利奈唑胺耐药基因与突变——一个难以控制的因素？

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本文引用的文献

1

Linezolid resistance in a clinical isolate of Staphylococcus aureus.金黄色葡萄球菌临床分离株中的利奈唑胺耐药性

Lancet. 2001 Jul 21;358(9277):207-8. doi: 10.1016/S0140-6736(01)05410-1.

2

Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.对利奈唑胺的耐药性：rRNA中突变的特征及其在耐万古霉素肠球菌中的发生率比较

Antimicrob Agents Chemother. 2001 Jul;45(7):2154-6. doi: 10.1128/AAC.45.7.2154-2156.2001.

3

Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid.耐万古霉素的屎肠球菌对利奈唑胺耐药导致的感染。

Lancet. 2001 Apr 14;357(9263):1179. doi: 10.1016/S0140-6736(00)04376-2.

4

Diversity of domain V of 23S rRNA gene sequence in different Enterococcus species.不同肠球菌属中23S rRNA基因序列V结构域的多样性。

J Clin Microbiol. 2000 Nov;38(11):3991-3. doi: 10.1128/JCM.38.11.3991-3993.2000.

5

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.23 S rRNA中的耐药突变确定了蛋白质合成抑制剂利奈唑胺在核糖体肽基转移酶中心的作用位点。

J Mol Biol. 1999 Nov 19;294(1):93-101. doi: 10.1006/jmbi.1999.3247.

6

A polyclonal outbreak of predominantly VanB vancomycin-resistant enterococci in northeast Ohio. Northeast Ohio Vancomycin-Resistant Enterococcus Surveillance Program.俄亥俄州东北部主要为VanB型耐万古霉素肠球菌的多克隆暴发。俄亥俄州东北部耐万古霉素肠球菌监测项目。

Clin Infect Dis. 1999 Sep;29(3):573-9. doi: 10.1086/598636.

7

Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate.一株临床耐万古霉素屎肠球菌分离株中含vanB新型转座子（Tn5382）与低亲和力青霉素结合蛋白5基因的遗传连锁及共转移

J Bacteriol. 1998 Sep;180(17):4426-34. doi: 10.1128/JB.180.17.4426-4434.1998.

8

Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.恶唑烷酮类药物的作用机制：利奈唑胺和依哌唑胺对翻译反应的影响。

Antimicrob Agents Chemother. 1997 Oct;41(10):2132-6. doi: 10.1128/AAC.41.10.2132.

粪肠球菌和屎肠球菌中的基因剂量与利奈唑胺耐药性

Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.

作者信息

Marshall S H, Donskey C J, Hutton-Thomas R, Salata R A, Rice L B

机构信息

Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

出版信息

Antimicrob Agents Chemother. 2002 Oct;46(10):3334-6. doi: 10.1128/AAC.46.10.3334-3336.2002.

DOI:10.1128/AAC.46.10.3334-3336.2002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC128780/

Abstract

Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.

摘要

对利奈唑胺的耐药性与23S rRNA结构域V中的G2576U突变有关。我们分析了9株耐利奈唑胺肠球菌的临床分离株，结果显示含有该突变的23S rRNA基因数量与所表现出的利奈唑胺耐药水平之间存在明显关联。