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1
Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.粪肠球菌和屎肠球菌中的基因剂量与利奈唑胺耐药性
Antimicrob Agents Chemother. 2002 Oct;46(10):3334-6. doi: 10.1128/AAC.46.10.3334-3336.2002.
2
Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms.中国多中心研究中耐利奈唑胺的肠球菌和科氏葡萄球菌临床分离株：分子流行病学和耐药机制。
Int J Antimicrob Agents. 2013 Oct;42(4):317-21. doi: 10.1016/j.ijantimicag.2013.06.008. Epub 2013 Jul 20.
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Comparison of testing methods for detection of decreased linezolid susceptibility due to G2576T mutation of the 23S rRNA gene in Enterococcus faecium and Enterococcus faecalis.粪肠球菌和屎肠球菌中因23S rRNA基因G2576T突变导致的利奈唑胺敏感性降低的检测方法比较
J Clin Microbiol. 2006 Mar;44(3):1098-100. doi: 10.1128/JCM.44.3.1098-1100.2006.
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Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium.重症监护病房中耐(linezolid)利奈唑烷(Enterococcus faecalis)肠球菌和屎肠球菌的多个克隆株的传播。
J Antimicrob Chemother. 2012 Aug;67(8):1819-23. doi: 10.1093/jac/dks146. Epub 2012 Apr 24.
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Molecular detection of linezolid resistance in Enterococcus faecium and Enterococcus faecalis by use of 5' nuclease real-time PCR compared to a modified classical approach.与改良经典方法相比，利用5'核酸酶实时聚合酶链反应对粪肠球菌和屎肠球菌中利奈唑胺耐药性进行分子检测。
J Clin Microbiol. 2004 Nov;42(11):5327-31. doi: 10.1128/JCM.42.11.5327-5331.2004.
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Linezolid-resistant enterococci in Greece: epidemiological characteristics.希腊耐(linezolid)利福霉素肠球菌：流行病学特征。
Chemotherapy. 2011;57(3):181-5. doi: 10.1159/000326444. Epub 2011 Apr 6.
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Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.耐利奈唑胺粪肠球菌引起的医院内二重感染：基因剂量对利奈唑胺最低抑菌浓度影响的证据
Diagn Microbiol Infect Dis. 2003 Nov;47(3):511-3. doi: 10.1016/s0732-8893(03)00153-6.
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In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci.恶唑烷酮类药物RWJ-416457对耐利奈唑胺和对利奈唑胺敏感的葡萄球菌及肠球菌的体外活性
Antimicrob Agents Chemother. 2007 Mar;51(3):1112-4. doi: 10.1128/AAC.01347-06. Epub 2007 Jan 8.
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Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.从一名脐血移植受者中分离出的耐利奈唑胺粪肠球菌。
J Clin Microbiol. 2004 Apr;42(4):1843-5. doi: 10.1128/JCM.42.4.1843-1845.2004.
引用本文的文献
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Linezolid in the Focus of Antimicrobial Resistance of Species: A Global Overview of Genomic Studies.利奈唑胺在细菌耐药性研究中的焦点：基因组研究的全球概述
Int J Mol Sci. 2025 Aug 24;26(17):8207. doi: 10.3390/ijms26178207.
2
Genomics to understand the global landscape of linezolid resistance in and .利用基因组学了解[具体对象1]和[具体对象2]中利奈唑胺耐药性的整体情况。
Microb Genom. 2025 Jun;11(6). doi: 10.1099/mgen.0.001432.
3
Vancomycin-Resistant : Addressing Global and Clinical Challenges.耐万古霉素：应对全球和临床挑战。
Antibiotics (Basel). 2025 May 19;14(5):522. doi: 10.3390/antibiotics14050522.
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Diversity in Adaptive Evolution of Methicillin-Resistant Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro.耐甲氧西林临床分离株在体外持续暴露于利奈唑胺压力下适应性进化的多样性
Infect Drug Resist. 2025 Feb 11;18:819-834. doi: 10.2147/IDR.S493139. eCollection 2025.
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: insights into epidemiology, virulence, and antimicrobial resistance of a clinically relevant bacterial species.深入了解临床相关细菌物种的流行病学、毒力和抗微生物耐药性。
Clin Microbiol Rev. 2024 Sep 12;37(3):e0011823. doi: 10.1128/cmr.00118-23. Epub 2024 Jun 20.
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ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics.ESKAPE 病原体：抗微生物药物耐药性、流行病学、临床影响和治疗学。
Nat Rev Microbiol. 2024 Oct;22(10):598-616. doi: 10.1038/s41579-024-01054-w. Epub 2024 Jun 3.
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Emergence of OptrA Gene Mediated Linezolid Resistance among Enterococcus Faecium: A Pilot Study from a Tertiary Care Hospital, India.粪肠球菌中optrA基因介导的利奈唑胺耐药性的出现：来自印度一家三级护理医院的初步研究
Int J Mol Cell Med. 2023;12(3):242-256. doi: 10.22088/IJMCM.BUMS.12.3.242.
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Antibiotic Resistance to Molecules Commonly Prescribed for the Treatment of Antibiotic-Resistant Gram-Positive Pathogens: What Is Relevant for the Clinician?对常用于治疗耐抗生素革兰氏阳性病原体的分子的抗生素耐药性：临床医生应关注什么？
Pathogens. 2024 Jan 19;13(1):88. doi: 10.3390/pathogens13010088.
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Linezolid Resistance Genes and Mutations among Linezolid-Susceptible spp.-A Loose Cannon?利奈唑胺敏感菌中的利奈唑胺耐药基因与突变——一个难以控制的因素？
Antibiotics (Basel). 2024 Jan 19;13(1):101. doi: 10.3390/antibiotics13010101.
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Emergence of linezolid-resistant in a tertiary hospital in Copenhagen.在哥本哈根的一家三级医院出现了耐利奈唑胺的 。
Microb Genom. 2023 Jul;9(7). doi: 10.1099/mgen.0.001055.
本文引用的文献
1
Linezolid resistance in a clinical isolate of Staphylococcus aureus.金黄色葡萄球菌临床分离株中的利奈唑胺耐药性
Lancet. 2001 Jul 21;358(9277):207-8. doi: 10.1016/S0140-6736(01)05410-1.
2
Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.对利奈唑胺的耐药性：rRNA中突变的特征及其在耐万古霉素肠球菌中的发生率比较
Antimicrob Agents Chemother. 2001 Jul;45(7):2154-6. doi: 10.1128/AAC.45.7.2154-2156.2001.
3
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid.耐万古霉素的屎肠球菌对利奈唑胺耐药导致的感染。
Lancet. 2001 Apr 14;357(9263):1179. doi: 10.1016/S0140-6736(00)04376-2.
4
Diversity of domain V of 23S rRNA gene sequence in different Enterococcus species.不同肠球菌属中23S rRNA基因序列V结构域的多样性。
J Clin Microbiol. 2000 Nov;38(11):3991-3. doi: 10.1128/JCM.38.11.3991-3993.2000.
5
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.23 S rRNA中的耐药突变确定了蛋白质合成抑制剂利奈唑胺在核糖体肽基转移酶中心的作用位点。
J Mol Biol. 1999 Nov 19;294(1):93-101. doi: 10.1006/jmbi.1999.3247.
6
A polyclonal outbreak of predominantly VanB vancomycin-resistant enterococci in northeast Ohio. Northeast Ohio Vancomycin-Resistant Enterococcus Surveillance Program.俄亥俄州东北部主要为VanB型耐万古霉素肠球菌的多克隆暴发。俄亥俄州东北部耐万古霉素肠球菌监测项目。
Clin Infect Dis. 1999 Sep;29(3):573-9. doi: 10.1086/598636.
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Genetic linkage and cotransfer of a novel, vanB-containing transposon (Tn5382) and a low-affinity penicillin-binding protein 5 gene in a clinical vancomycin-resistant Enterococcus faecium isolate.一株临床耐万古霉素屎肠球菌分离株中含vanB新型转座子（Tn5382）与低亲和力青霉素结合蛋白5基因的遗传连锁及共转移
J Bacteriol. 1998 Sep;180(17):4426-34. doi: 10.1128/JB.180.17.4426-4434.1998.
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Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.恶唑烷酮类药物的作用机制：利奈唑胺和依哌唑胺对翻译反应的影响。
Antimicrob Agents Chemother. 1997 Oct;41(10):2132-6. doi: 10.1128/AAC.41.10.2132.
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