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Quinupristin-dalfopristin and linezolid: evidence and opinion.奎奴普丁-达福普汀与利奈唑胺：证据与观点。
Clin Infect Dis. 2003 Feb 15;36(4):473-81. doi: 10.1086/367662. Epub 2003 Jan 31.
2
Linezolid: the first oxazolidinone antimicrobial.利奈唑胺：首个恶唑烷酮类抗菌药物。
Ann Intern Med. 2003 Jan 21;138(2):135-42. doi: 10.7326/0003-4819-138-2-200301210-00015.
3
Multicentre assessment of linezolid antimicrobial activity and spectrum in Europe: report from the Zyvox antimicrobial potency study (ZAPS-Europe).欧洲利奈唑胺抗菌活性及抗菌谱的多中心评估：来自斯沃抗菌效力研究（ZAPS-欧洲）的报告
Clin Microbiol Infect. 2002 Dec;8(12):791-800. doi: 10.1046/j.1469-0691.2002.00484.x.
4
Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit.从奥地利同一重症监护病房的两名患者中分离出的新型耐利奈唑胺粪肠球菌和屎肠球菌。
Eur J Clin Microbiol Infect Dis. 2002 Oct;21(10):751-4. doi: 10.1007/s10096-002-0807-0. Epub 2002 Sep 13.
5
Risk factors for development of vancomycin-resistant enterococcal bloodstream infection in patients with cancer who are colonized with vancomycin-resistant enterococci.携带耐万古霉素肠球菌的癌症患者发生耐万古霉素肠球菌血流感染的危险因素。
Clin Infect Dis. 2002 Nov 15;35(10):1139-46. doi: 10.1086/342904. Epub 2002 Oct 17.
6
Detection of oxazolidinone-resistant Enterococcus faecalis and Enterococcus faecium strains by real-time PCR and PCR-restriction fragment length polymorphism analysis.通过实时荧光定量聚合酶链反应和聚合酶链反应-限制性片段长度多态性分析检测耐恶唑烷酮粪肠球菌和屎肠球菌菌株
J Clin Microbiol. 2002 Nov;40(11):4298-300. doi: 10.1128/JCM.40.11.4298-4300.2002.
7
Linezolid-resistant enterococci: report of the first isolates in the United Kingdom.耐利奈唑胺肠球菌：英国首例分离株报告
J Antimicrob Chemother. 2002 Nov;50(5):743-6. doi: 10.1093/jac/dkf246.
8
Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.粪肠球菌和屎肠球菌中的基因剂量与利奈唑胺耐药性
Antimicrob Agents Chemother. 2002 Oct;46(10):3334-6. doi: 10.1128/AAC.46.10.3334-3336.2002.
9
Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox(R) antimicrobial potency study in Latin America (LA-ZAPS).使用纸片扩散法和Etest法对利奈唑胺的抗菌谱和活性进行多中心评估：拉丁美洲Zyvox抗菌效力研究（LA-ZAPS）报告
Braz J Infect Dis. 2002 Jun;6(3):100-9. doi: 10.1590/s1413-86702002000300001.
10
A multicenter evaluation of linezolid antimicrobial activity in North America.北美利奈唑胺抗菌活性的多中心评估。
Diagn Microbiol Infect Dis. 2002 May;43(1):75-83. doi: 10.1016/s0732-8893(01)00334-0.

从一名脐血移植受者中分离出的耐利奈唑胺粪肠球菌。

Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.

作者信息

Dibo Imad, Pillai Satish K, Gold Howard S, Baer Maria R, Wetzler Meir, Slack James L, Hazamy Peggy A, Ball Donna, Hsiao Chiu Bin, McCarthy Philip L, Segal Brahm H

机构信息

Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.

出版信息

J Clin Microbiol. 2004 Apr;42(4):1843-5. doi: 10.1128/JCM.42.4.1843-1845.2004.

DOI:10.1128/JCM.42.4.1843-1845.2004
PMID:15071066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387622/
Abstract

We report a linezolid-resistant Enterococcus faecalis infection in a cord blood stem cell transplant recipient previously treated with linezolid for bloodstream infections by vancomycin-resistant enterococci. Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy.

摘要

我们报告了1例脐带血干细胞移植受者发生耐利奈唑胺粪肠球菌感染，该受者曾因耐万古霉素肠球菌血流感染接受过利奈唑胺治疗。测序显示23S rRNA基因存在G2576U突变。鉴于利奈唑胺在癌症治疗中的重要地位，耐利奈唑胺粪肠球菌值得关注。