Thomassen S A, Johannesen I L, Erlandsen E J, Abrahamsen J, Randers E
Department of Internal Medicine, Viborg-Kjellerup County Hospital, Viborg, Denmark.
Spinal Cord. 2002 Oct;40(10):524-8. doi: 10.1038/sj.sc.3101320.
To investigate the relationship between serum cystatin C, serum creatinine, and (51)Cr-EDTA-clearance in patients with spinal cord injury.
The Spinal Cord Unit, Viborg-Kjellerup County Hospital.
Twenty-four men and seven women aged 20.3 to 68.0 years with motor complete spinal cord injury (ASIA A or B) were included. Serum cystatin C was measured by an automated particle-enhanced nephelometric immunoassay (Dade Behring), serum creatinine by an enzymatic method (Vitros 950), and (51)Cr-EDTA-clearance by a multiple plasma sample method.
A linear relationship was found between (51)Cr-EDTA-clearance and the reciprocal values of cystatin C and creatinine. The correlation coefficient between (51)Cr-EDTA-clearance and 1/cystatin C was 0.72 compared to the correlation coefficient between (51)Cr-EDTA-clearance and 1/creatinine being 0.26. Comparison of the area under the curves in the non-parametric receiver operating characteristics (ROC) plots for serum cystatin C (area under the curve (AUC)=0.912; SE=0.065), and serum creatinine (AUC=0.507; SE=0.115) revealed significant differences (P-values=0.0005).
In patients with spinal cord injury serum cystatin C is a better marker of the renal function compared to serum creatinine.
研究脊髓损伤患者血清胱抑素C、血清肌酐与（51）铬-乙二胺四乙酸清除率之间的关系。
维堡-凯勒鲁普县医院脊髓科。
纳入24名男性和7名女性，年龄在20.3至68.0岁之间，均为运动完全性脊髓损伤（美国脊髓损伤协会分级A或B级）。血清胱抑素C采用自动颗粒增强散射比浊免疫测定法（德灵公司）测定，血清肌酐采用酶法（Vitros 950）测定，（51）铬-乙二胺四乙酸清除率采用多次血浆样本法测定。
（51）铬-乙二胺四乙酸清除率与胱抑素C和肌酐的倒数之间呈线性关系。（51）铬-乙二胺四乙酸清除率与1/胱抑素C的相关系数为0.72，而（51）铬-乙二胺四乙酸清除率与1/肌酐的相关系数为0.26。血清胱抑素C（曲线下面积（AUC）=0.912；标准误=0.065）和血清肌酐（AUC=0.507；标准误=0.115）的非参数受试者工作特征（ROC）曲线下面积比较显示出显著差异（P值=0.0005）。
在脊髓损伤患者中，与血清肌酐相比，血清胱抑素C是更好的肾功能标志物。
