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外周脱羧酶抑制对抑郁症患者脑脊液中高香草酸和5-羟吲哚乙酸的影响。

Effect of peripheral decarboxylase inhibition on HVA and 5HIAA in cerebrospinal fluid of depressed patients.

作者信息

Gaillard J M, Constantinidis J, Tissot R

出版信息

Neuropsychobiology. 1975;1(1):26-31. doi: 10.1159/000117472.

DOI:10.1159/000117472
PMID:1223666
Abstract

The effects of benserazide on the level of homovanillic acid and 5-hydroxyindoleacetic acid in CSF have been investigated in 1 manic and 11 depressed patients. Benserazide induced no change on both metabolites. This negative result supports the view that monoamine metabolites in CSF, in the absence of loading with an exogenous precursor, originate mostly from brain parenchyma, without significant contribution of the metabolism in capillary walls.

摘要

已对1名躁狂症患者和11名抑郁症患者研究了苄丝肼对脑脊液中高香草酸和5-羟吲哚乙酸水平的影响。苄丝肼对这两种代谢产物均未产生变化。这一阴性结果支持了以下观点：在没有外源性前体负荷的情况下，脑脊液中的单胺代谢产物主要源自脑实质，而毛细血管壁代谢的贡献不大。

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Neuropsychobiology. 1975;1(1):26-31. doi: 10.1159/000117472.
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