• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

电休克疗法和丙咪嗪治疗对抑郁症患者脑脊液中5-羟吲哚乙酸（5HIAA）和高香草酸（HVA）浓度的影响。

Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients.

作者信息

Jori A, Dolfini E, Casati C, Argenta G

出版信息

Psychopharmacologia. 1975 Oct 14;44(1):87-90. doi: 10.1007/BF00421189.

DOI:10.1007/BF00421189
PMID:1105628
Abstract

The influence of probenecid administration on 5HIAA and HVA concentrations in the CSF of depressed patients, was studied before and after treatment with imipramine or ECT. The average increase of the two metabolites in the CSF after probenecid was similar in the untreated depressed patients and in the same patients improved after both imipramine or ECT treatment. The treatment determined a significant increase in the CSF concentration of the acid metabolites also before the probenecid administration.

摘要

在使用丙磺舒治疗前及使用丙咪嗪或电休克治疗后，研究了丙磺舒给药对抑郁症患者脑脊液中5 -羟吲哚乙酸（5HIAA）和高香草酸（HVA）浓度的影响。在未经治疗的抑郁症患者以及经丙咪嗪或电休克治疗后病情改善的同一患者中，丙磺舒给药后脑脊液中这两种代谢物的平均增加量相似。治疗还使在给予丙磺舒之前脑脊液中酸性代谢物的浓度显著增加。

相似文献

1
Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients.电休克疗法和丙咪嗪治疗对抑郁症患者脑脊液中5-羟吲哚乙酸（5HIAA）和高香草酸（HVA）浓度的影响。
Psychopharmacologia. 1975 Oct 14;44(1):87-90. doi: 10.1007/BF00421189.
2
Concentration of 5-hydroxyindoleacetic acid, homovanillic acid, and tryptophan in the cerebrospinal fluid of depressed patients before and after ECT.抑郁症患者在接受电休克治疗前后脑脊液中5-羟吲哚乙酸、高香草酸和色氨酸的浓度。
Biol Psychiatry. 1976 Feb;11(1):85-90.
3
Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients.阿米替林和丙咪嗪对抑郁症患者脑脊液中胺类代谢物的影响。
Arch Gen Psychiatry. 1974 Feb;30(2):234-9. doi: 10.1001/archpsyc.1974.01760080082014.
4
Effect of peripheral decarboxylase inhibition on HVA and 5HIAA in cerebrospinal fluid of depressed patients.外周脱羧酶抑制对抑郁症患者脑脊液中高香草酸和5-羟吲哚乙酸的影响。
Neuropsychobiology. 1975;1(1):26-31. doi: 10.1159/000117472.
5
Probenecid: dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit.丙磺舒：家兔的剂量、血浆和脑脊液（CSF）中的水平以及对脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）水平的影响。
Psychopharmacologia. 1975 Sep 17;43(3):223-7. doi: 10.1007/BF00429254.
6
Serotonin and dopamine disturbances in patients with unipolar depression and Parkinsonism.单相抑郁症和帕金森病患者的血清素和多巴胺紊乱
Adv Exp Med Biol. 1981;133:753-67. doi: 10.1007/978-1-4684-3860-4_42.
7
Biogenic amine disturbances in cerebrospinal fluid in parkinsonism and unipolar depression: use of the probenecid method.帕金森病和单相抑郁症患者脑脊液中生物胺的紊乱：丙磺舒法的应用
Neuropsychobiology. 1981;7(3):137-51. doi: 10.1159/000117843.
8
Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline.丙磺舒治疗后，接受阿米替林治疗的单相抑郁症患者脑脊液中5-羟吲哚乙酸（5HIAA）和高香草酸（HVA）的情况
Psychopharmacologia. 1972;23(1):26-33. doi: 10.1007/BF00414411.
9
[Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (HIAA) in the CSF after administration of probenecid in Huntington's chorea. Effect of lithium carbonate].[丙磺舒给药后亨廷顿舞蹈病患者脑脊液中高香草酸（HVA）和5-羟吲哚乙酸（HIAA）的含量。碳酸锂的影响]
Riv Neurobiol. 1977 Jul-Sep;23(3):149-59.
10
Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls.抑郁症患者、自杀患者及健康对照者的血小板单胺氧化酶活性和脑脊液中的单胺代谢产物
Psychiatry Res. 1981 Feb;4(1):21-9. doi: 10.1016/0165-1781(81)90004-4.

引用本文的文献

1
Noninvasive Therapies: A Forthcoming Approach to Parkinson's Treatment.非侵入性疗法：帕金森病治疗的未来途径。
CNS Neurol Disord Drug Targets. 2025;24(3):165-180. doi: 10.2174/0118715273318429240812094557.
2
Dynamic quantitative monitoring of cerebrospinal fluid monoamine neurotransmitter markers during the modeling process of chronic stress-induced depression in monkeys (Macaca mulatta).在猕猴慢性应激诱导抑郁模型制作过程中对脑脊液单胺类神经递质标志物的动态定量监测。
Brain Behav. 2024 Aug;14(8):e3636. doi: 10.1002/brb3.3636.
3
Non-Invasive Brain Stimulation Effects on Biomarkers of Tryptophan Metabolism: A Scoping Review and Meta-Analysis.

本文引用的文献

1
Biochemical and pharmacological effects induced by electroshock.电击诱导的生化和药理作用。
Psychiatr Neurol (Basel). 1960 Jul;140:190-206. doi: 10.1159/000131258.
2
Cerebrospinal fluid 5-hydroxyindoleactiic acid and homovanillic acid in psychiatric patients.精神疾病患者脑脊液中的5-羟吲哚乙酸和高香草酸
Int J Neuropharmacol. 1969 May;8(3):255-62. doi: 10.1016/0028-3908(69)90046-x.
3
Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: A biochemical classification?伴有和不伴有5-羟色胺代谢紊乱的内源性抑郁症：一种生化分类？
非侵入性脑刺激对色氨酸代谢生物标志物的影响：范围综述和荟萃分析。
Int J Mol Sci. 2022 Aug 26;23(17):9692. doi: 10.3390/ijms23179692.
4
5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology.5-羟色胺与抑郁症：正常变异与病理相互作用的模型
Br J Clin Pharmacol. 1983;15 Suppl 3(Suppl 3):393S-405S. doi: 10.1111/j.1365-2125.1983.tb02130.x.
5
Platelet serotonin transport after a single ECT.单次电休克治疗后的血小板5-羟色胺转运
Psychopharmacology (Berl). 1988;95(1):139-41. doi: 10.1007/BF00212783.
6
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.抑郁女性焦虑及相关症状与脑脊液5-羟吲哚乙酸的相关性
J Neural Transm. 1977;41(2-3):135-43. doi: 10.1007/BF01670278.
7
Alterations of cerebrospinal fluid 5-hydroxyindoleacetic acid, and total blood serotonin content during clozapine treatment.氯氮平治疗期间脑脊液5-羟吲哚乙酸及全血血清素含量的变化
Psychopharmacology (Berl). 1978 Mar 1;56(2):195-8. doi: 10.1007/BF00431849.
Psychopharmacologia. 1971;19(2):148-52. doi: 10.1007/BF00402638.
4
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.丙磺舒作用后人体脑脊液中生物胺代谢物迅速升高。
Life Sci I. 1970 Dec 15;9(24):1397-408. doi: 10.1016/0024-3205(70)90134-7.
5
5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid.丙磺舒治疗的抑郁症患者脑脊液中5-羟吲哚乙酸水平
Nature. 1970 Mar 28;225(5239):1259-60. doi: 10.1038/2251259b0.
6
A spectrofluorometric method for the simultaneous determination of 2-(5-hydroxyindol-3-yl) ethylamine (serotonin) and 5-hydroxyindol-3-yl-acetic acid in the brain.一种用于同时测定脑中2-(5-羟基吲哚-3-基)乙胺（血清素）和5-羟基吲哚-3-基乙酸的荧光分光光度法。
Pharmacology. 1969;2(3):171-5. doi: 10.1159/000136013.
7
Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.静脉注射丙磺舒对人体脑脊液中5-羟吲哚乙酸、高香草酸和3-甲氧基-4-羟基苯乙二醇水平的影响。
Biochem Pharmacol. 1971 Mar;20(3):659-68. doi: 10.1016/0006-2952(71)90152-3.
8
Amine metabolism in the human brain: further evaluation of the probenecid test.人脑中的胺代谢：丙磺舒试验的进一步评估。
Brain Res. 1971 Dec 10;35(1):221-30. doi: 10.1016/0006-8993(71)90607-x.
9
Homovanillic and 5-hydroxyindoleacetic acid in cerebrospinal fluid of depressed patients.抑郁症患者脑脊液中的高香草酸和5-羟吲哚乙酸
Arch Gen Psychiatry. 1971 Oct;25(4):354-8. doi: 10.1001/archpsyc.1971.01750160066012.
10
Origin of 5-hydroxyindoleacetic acid in the spinl fluid.脊髓液中5-羟吲哚乙酸的来源。
Science. 1971 Aug 20;173(3998):738-40. doi: 10.1126/science.173.3998.738.