与宫颈人乳头瘤病毒感染相关的雌激素受体转录物
Oestrogen receptor transcripts associated with cervical human papillomavirus infection.
作者信息
Shew M L, McGlennen R, Zaidi N, Westerheim M, Ireland M, Anderson S
机构信息
Division of General Pediatrics, University of Minnesota, Minneapolis, USA.
出版信息
Sex Transm Infect. 2002 Jun;78(3):210-4. doi: 10.1136/sti.78.3.210.
OBJECTIVE
Studies have been inconsistent in establishing sex steroids as a risk factor for human papillomavirus (HPV) infections. This study was designed to determine whether cervical oestrogen receptors (as measured by oestrogen receptor transcripts) at the cervix would be associated with cervical HPV infections.
METHODS
In 175 women, ages 14-44, we tested for the presence of HPV DNA and oestrogen receptors transcripts at the cervix during routine pelvic examinations. All subjects completed a self administered questionnaire regarding sexual and menstrual histories.
RESULTS
40% of the women (n=70) tested positive for HPV at the cervix. Of those women testing positive for HPV, 99% had detectable levels of Oestrogen receptors transcripts (n=69/70). HPV cervical infections were independently associated with presence of Oestrogen receptors transcripts (OR=39.8, CI=4.4, 361.1) and greater numbers of sexual partners (OR=1.1, CI=1.01, 1.18).
CONCLUSION
Women who expressed higher levels of oestrogen receptors transcripts were significantly more likely to have cervical HPV infection. These results demonstrate that Oestrogen receptors may play an important part in cervical HPV infections.
目的
关于将性类固醇确定为人类乳头瘤病毒（HPV）感染的风险因素，各项研究结果并不一致。本研究旨在确定宫颈处的雌激素受体（通过雌激素受体转录本测定）是否与宫颈HPV感染相关。
方法
在175名年龄在14至44岁的女性中，我们在常规盆腔检查期间检测了宫颈处HPV DNA和雌激素受体转录本的存在情况。所有受试者都完成了一份关于性史和月经史的自我调查问卷。
结果
40%的女性（n = 70）宫颈HPV检测呈阳性。在那些HPV检测呈阳性的女性中，99%有可检测到的雌激素受体转录本水平（n = 69/70）。宫颈HPV感染与雌激素受体转录本的存在（OR = 39.8，CI = 4.4，361.1）以及更多性伴侣数量（OR = 1.1，CI = 1.01，1.18）独立相关。
结论
表达较高水平雌激素受体转录本的女性患宫颈HPV感染的可能性显著更高。这些结果表明雌激素受体可能在宫颈HPV感染中起重要作用。
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