Drzezga Alexander, Grimmer Timo, Siebner Hartwig, Minoshima Satoshi, Schwaiger Markus, Kurz Alexander
Nuklearmedizinische Klinik u. Poliklinik, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany.
J Neurol. 2002 Sep;249(9):1263-7. doi: 10.1007/s00415-002-0832-z.
Primary progressive aphasia (PPA) is characterized by progressive deterioration of language function with relative preservation of other cognitive functions. Previous studies based on neuroimaging and histology point to predominantly left temporal pathology in PPA patients. Here we report two left-handed subjects with typical symptoms of the nonfluent form of PPA in whom 18F-FDG PET revealed an asymmetric right-hemispheric pattern of reduced glucose metabolism in the frontal and temporoparietal cortex. These findings support the hypothesis that PPA can be considered as a symptom complex rather than a disease entity.
原发性进行性失语（PPA）的特征是语言功能进行性恶化，而其他认知功能相对保留。以往基于神经影像学和组织学的研究表明，PPA患者主要存在左侧颞叶病变。在此，我们报告了两名左利手受试者，他们具有非流利型PPA的典型症状，18F-FDG PET显示其额叶和颞顶叶皮质葡萄糖代谢呈不对称的右侧半球减低模式。这些发现支持了PPA可被视为一种症状复合体而非疾病实体的假说。
