Perneczky Robert, Diehl-Schmid Janine, Pohl Corina, Drzezga Alexander, Kurz Alexander
Departments of Psychiatry and Psychotherapy, Technische Universität München, Germany.
Brain Res. 2007 Feb 16;1133(1):178-85. doi: 10.1016/j.brainres.2006.11.054. Epub 2006 Dec 20.
Functional imaging studies suggest that brain reserve allows patients with Alzheimer's disease with more years of schooling to cope better with brain damage. No studies exist on patients with non-fluent progressive aphasia (NFPA). We aimed to explore metabolic patterns of patients with NFPA and to provide evidence for brain reserve in NFPA. 11 right-handed patients with NFPA and 16 age-matched controls underwent (18)F-FDG PET imaging. Scans of patients and controls were compared in SPM2. A linear regression analysis with glucose metabolism as dependent variable and years of schooling as the independent variable, adjusted for age, gender, and a total score of the CERAD neuropsychological battery was conducted. The NFPA group showed a hypometabolism of the left hemisphere including the middle frontal, and inferior temporal and angular gyri, and the bilateral caudate nuclei and thalami (p(corr)<0.05). The regression analysis revealed a significant inverse association between education and glucose metabolism in the left inferior temporal, parahippocampal, and supramarginal gyri (p(corr)<0.05). We conclude that brain reserve is also present in NFPA.
功能成像研究表明，脑储备使受教育年限更长的阿尔茨海默病患者能更好地应对脑损伤。目前尚无针对非流畅性进行性失语（NFPA）患者的研究。我们旨在探究NFPA患者的代谢模式，并为NFPA的脑储备提供证据。11名右利手NFPA患者和16名年龄匹配的对照者接受了（18）F-FDG PET成像检查。在SPM2中对患者和对照者的扫描结果进行比较。以葡萄糖代谢为因变量、受教育年限为自变量进行线性回归分析，并对年龄、性别和CERAD神经心理量表总分进行校正。NFPA组显示左半球代谢减低，包括额中回、颞下回和角回，以及双侧尾状核和丘脑（p（校正）<0.05）。回归分析显示，在左下颞叶、海马旁回和缘上回，受教育程度与葡萄糖代谢之间存在显著负相关（p（校正）<0.05）。我们得出结论，NFPA患者也存在脑储备。
