Hamir A N, Smith B B
National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA.
Vet Pathol. 2002 Sep;39(5):592-4. doi: 10.1354/vp.39-5-592.
An adult alpaca (Lama pacos) had a locally extensive area of hepatic atrophy involving the right lobe. Grossly, the atrophic lobe was light tan and firm and contained small, raised, white to yellow, partially mineralized circular nodules predominantly at the periphery of the atrophic tissue. Microscopically, viable hepatocytes were not present in the atrophic area, and the tissue consisted of diffuse biliary epithelial proliferation without any evidence of nuclear or cellular atypia or the presence of mitotic figures. The circular mineralized nodules consisted of granulomatous inflammation with intralesional parasitic ova surrounded by fibrous connective tissue. Morphologically, the ova were compatible with those of Fasciola hepatica. The severe biliary hyperplasia was unusual, and it was not clear whether it was caused by an aberrant host response to the parasitic infection or whether it was an unrelated event.
一只成年羊驼（小羊驼）右叶出现局部广泛的肝萎缩区域。大体上，萎缩的叶呈浅棕褐色且质地坚硬，包含小的、隆起的、白色至黄色、部分矿化的圆形结节，主要位于萎缩组织的周边。显微镜下，萎缩区域不存在存活的肝细胞，组织由弥漫性胆管上皮增生构成，没有任何核或细胞异型性的证据，也没有有丝分裂象。圆形矿化结节由肉芽肿性炎症组成，病灶内有寄生虫卵，周围为纤维结缔组织。形态学上，这些虫卵与肝片吸虫的虫卵相符。严重的胆管增生并不常见，尚不清楚它是由宿主对寄生虫感染的异常反应引起，还是与寄生虫感染无关的事件。
