Bulpitt C J
Br Heart J. 1975 Dec;37(12):1210-5. doi: 10.1136/hrt.37.12.1210.
Both the average serum uric acid and annual increment were determined in 250 treated patients attending a hypertension clinic. The average serum uric acid was greater in men compared with women, in patients receiving a thiazide diuretic and in patients with a high average plasma urea. The mean annual increment in uric acid was close to zero (0.0017 mmol/litre per year) and was not related to sex, age, blood pressure control, diuretic therapy, or plasma urea. There was an unexplained positive association between annual increment and methyldopa therapy though this drug was not associated with a significantly high average serum uric acid. A table is presented giving the theoretical upper limits for average serum uric acid according to sex, plasma urea concentration, and whether or not a thiazide diuretic has been prescribed. It is hoped that this table will be of assistance in assessing the normality or otherwise of a high serum uric acid found in a hypertensive patient.
对一家高血压诊所的250名接受治疗的患者测定了平均血清尿酸水平和年增加量。男性患者、接受噻嗪类利尿剂治疗的患者以及平均血浆尿素水平较高的患者，其平均血清尿酸水平更高。尿酸的年均增加量接近零（每年0.0017毫摩尔/升），且与性别、年龄、血压控制情况、利尿剂治疗或血浆尿素无关。尽管甲基多巴治疗与显著升高的平均血清尿酸水平无关，但年均增加量与甲基多巴治疗之间存在一种无法解释的正相关关系。文中给出了一个表格，根据性别、血浆尿素浓度以及是否开具了噻嗪类利尿剂，列出了平均血清尿酸的理论上限。希望该表格有助于评估高血压患者血清尿酸升高是否正常。
