Balázs M, Elö J, Juhász J
HNO. 1975 Feb;23(2):35-42.
The authors report the case of a 50 year old male patient whose rhinoscleroma, localized to the upper respiratory tract, was demonstrated by the isolation of Klebsiella bacilli and histologically. Electron microscopically the Mikulicz cells were characterized by fused vacuoles occupying the largest portion of the cytoplasm and displacing the damaged cytoplasmic organelles. Phagosomes and dense bodies reminiscent of Russel bodies also occurred in the Mikulicz cells, in the vacuoles of which formations representing Klebsiella rhinoscleromatis were demonstrated. A light halo was visible around some of these formations. It could not be, however, decided whether these halos represented the mucous sheath of the bacillus or an artifact only. In the plasmacells the authors observed the bag-like dilatation of the ergastoplasm and the presence of Russel bodies. Transitory forms were not seen among the plasma and Mikulicz cells. As a result of the treatment, Klebsiella disappeared from the nasal mucosa of the patient. The authors wish to follow by means of electron microscopy the changes of the granulation tissue and pathogens following antibiotic therapy.
作者报告了一例50岁男性患者的病例，其鼻硬结病局限于上呼吸道，通过分离克雷伯菌属杆菌并进行组织学检查得以证实。电镜下，米库利奇细胞的特征是融合的空泡占据了细胞质的大部分，并取代了受损的细胞质细胞器。吞噬体和类似鲁塞尔小体的致密体也出现在米库利奇细胞中，在其空泡中显示出代表鼻硬结克雷伯菌的结构。在其中一些结构周围可见淡光环。然而，无法确定这些光环是代表杆菌的黏液鞘还是仅仅是一种假象。在浆细胞中，作者观察到内质网呈袋状扩张以及鲁塞尔小体的存在。在浆细胞和米库利奇细胞中未见到过渡形式。经过治疗，克雷伯菌从患者的鼻黏膜中消失。作者希望通过电子显微镜观察抗生素治疗后肉芽组织和病原体的变化。
