Kaya M, Harrison R G
J Pathol. 1975 Oct;117(2):105-17. doi: 10.1002/path.1711170209.
Permanent ischaemia of the rat testis results in the formation of fusion multinucleate cells and macrophages from cells of the innermost cellular layer, in the ischaemic testis. The macrophages are replaced by fibroblasts after 25 days of ischaemia. Similar changes are visible in the contralateral testis which also demonstrates the evolution of multinucleate spermatids by karyokinesis without cytokinesis. Binucleate spermatids and double-headed spermatozoa have only one acrosome, and spermatozoa with two middle pieces are enveloped by a single cytoplasm. The sequential ultrastructural changes following ischaemia are described and it is suggested that cells of the inner cellular layer can alter their characteristics according to demand.
大鼠睾丸的永久性缺血会导致缺血睾丸最内层细胞形成融合多核细胞和巨噬细胞。缺血25天后，巨噬细胞被成纤维细胞取代。对侧睾丸也可见类似变化，其也显示了多核精子细胞通过核分裂而无胞质分裂的演变过程。双核精子细胞和双头精子只有一个顶体，有两个中段的精子被单个细胞质包裹。文中描述了缺血后的一系列超微结构变化，并提出最内层细胞可根据需要改变其特征。
