Rowe R C
J Pharm Pharmacol. 1977 Dec;29(12):723-6. doi: 10.1111/j.2042-7158.1977.tb11449.x.
The effect of some direct compression excipients and lubricants on the adhesion of hydroxypropyl methyl cellulose films has been examined using a specially designed tensile testing apparatus (Fisher & Rowe, 1976). The adhesion was found to be influenced by both the roughness, including microporosity, of the tablet surface and its polarity. Tablets prepared from microcrystalline cellulose showed very high adhesions despite having relatively smooth surfaces, owing to the surface being saturated with hydroxyl groups able to form hydrogen bonds with the corresponding groups on the polymer. The addition of magnesium or calcium stearate to the tablet was found to decrease the adhesion, but the addition of stearic acid caused a significant increase. The effect of lubricant concentration on the adhesion could be expressed by an equation similar to that proposed by Hofrichter & McLaren (1948) for the adhesion of vinyl chloride/vinyl acetate copolymers to regenerated cellulose.
使用专门设计的拉伸试验装置（Fisher & Rowe，1976年）研究了一些直接压片辅料和润滑剂对羟丙基甲基纤维素薄膜黏附性的影响。发现黏附性受片剂表面粗糙度（包括微孔率）及其极性的影响。由微晶纤维素制备的片剂尽管表面相对光滑，但由于表面被能够与聚合物上相应基团形成氢键的羟基所饱和，因而显示出非常高的黏附性。发现向片剂中添加硬脂酸镁或硬脂酸钙会降低黏附性，但添加硬脂酸会导致显著增加。润滑剂浓度对黏附性的影响可用一个类似于Hofrichter & McLaren（1948年）提出的关于氯乙烯/醋酸乙烯酯共聚物与再生纤维素黏附性的方程来表示。
