Eckert H, Jerochin S
Z Erkr Atmungsorgane. 1978 Jan;150(1):34-42.
Phagocytosis of foreign body material (mineral oil) by alveolar macrophages and interstitial localized macrophages is seen in early stages of mineral oil pneumonia studied by electron microscopy and histochemistry. Degradation of phagocytized mineral oil by phagolysosomes is seen in alveolar macrophages, appearing in final stages as empty vacuoles. In contrast, this hydrolytic degradation cannot be found in interstitially localized macrophages. In these cells the mineral oil is present in unchanged form. It seems to be likely that this retention of foreign body material is the reason of granuloma formation. As a non-specific result of mineral oil application there is observed an increased production and extrusion of osmiophilic material (surface active phospholipids) by large alveolar epithel cells.
在通过电子显微镜和组织化学研究的矿物油肺炎早期阶段，可见肺泡巨噬细胞和间质局部巨噬细胞对异物物质（矿物油）的吞噬作用。在肺泡巨噬细胞中可见吞噬溶酶体对吞噬的矿物油进行降解，最终阶段呈现为空泡。相比之下，在间质局部巨噬细胞中未发现这种水解降解。在这些细胞中，矿物油以未改变的形式存在。异物物质的这种留存似乎是肉芽肿形成的原因。作为应用矿物油的非特异性结果，观察到大型肺泡上皮细胞产生并排出嗜锇物质（表面活性磷脂）增加。
