Paulsen Ian T, Seshadri Rekha, Nelson Karen E, Eisen Jonathan A, Heidelberg John F, Read Timothy D, Dodson Robert J, Umayam Lowell, Brinkac Lauren M, Beanan Maureen J, Daugherty Sean C, Deboy Robert T, Durkin A Scott, Kolonay James F, Madupu Ramana, Nelson William C, Ayodeji Bola, Kraul Margaret, Shetty Jyoti, Malek Joel, Van Aken Susan E, Riedmuller Steven, Tettelin Herve, Gill Steven R, White Owen, Salzberg Steven L, Hoover David L, Lindler Luther E, Halling Shirley M, Boyle Stephen M, Fraser Claire M
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. doi: 10.1073/pnas.192319099. Epub 2002 Sep 23.
The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.
测定了细胞内病原体及潜在生物恐怖主义因子猪布鲁氏菌的331万个碱基对的基因组序列。将猪布鲁氏菌与羊布鲁氏菌进行比较，确定了一组有限的差异，这些差异可能是导致这些生物体毒力和宿主偏好不同的原因，并表明噬菌体在它们的分化过程中发挥了重要作用。对猪布鲁氏菌基因组的分析揭示了其与土壤/植物相关细菌相似的转运和代谢能力。猪布鲁氏菌1号染色体与植物共生菌百脉根中生根瘤菌的基因组之间存在广泛的基因共线性，这突出了这种动物病原体与植物病原体及共生菌之间的相似性。鉴定出了与已知细菌毒力因子同源的有限基因库。
