Delrue Rose-May, Lestrate Pascal, Tibor Anne, Letesson Jean-Jacques, De Bolle Xavier
Unité de Recherche en Biologie Moléculaire (URBM), Laboratoire d'Immunologie et de Microbiologie, Université de Namur, Namur, Belgium.
FEMS Microbiol Lett. 2004 Feb 9;231(1):1-12. doi: 10.1016/S0378-1097(03)00963-7.
Pathogenicity islands, specialized secretion systems, virulence plasmids, fimbriae, pili, adhesins, and toxins are all classical bacterial virulence factors. However, many of these factors, though widespread among bacterial pathogens, are not necessarily found among bacteria that colonize eukaryotic cells in a pathogenic/symbiotic relationship. Bacteria that form these relationships have developed other strategies to infect and grow in their hosts. This is particularly true for Brucella and other members of the class Proteobacteria. Thus far the identification of virulence factors for Brucella has been largely dependent on large-scale screens and testing in model systems. The genomes of the facultative intracellular pathogens Brucella melitensis and Brucella suis were sequenced recently. This has identified several more potential virulence factors for Brucella that were not found in large screens. Here, we present an overall view of Brucella virulence by compiling virulence data from the study of 184 attenuated mutants.
致病岛、特殊分泌系统、毒力质粒、菌毛、菌毛、黏附素和毒素都是经典的细菌毒力因子。然而，这些因子中的许多虽然在细菌病原体中广泛存在，但在以致病/共生关系定殖于真核细胞的细菌中不一定能找到。形成这些关系的细菌已经开发出其他策略来感染宿主并在其中生长。布鲁氏菌属和其他变形菌纲成员尤其如此。到目前为止，布鲁氏菌毒力因子的鉴定在很大程度上依赖于在模型系统中的大规模筛选和测试。兼性胞内病原体羊种布鲁氏菌和猪种布鲁氏菌的基因组最近已被测序。这确定了一些在大规模筛选中未发现的布鲁氏菌潜在毒力因子。在这里，我们通过汇编184个减毒突变体的研究中的毒力数据，对布鲁氏菌毒力进行了全面概述。
