[The cytochemistry of phagocytic cells in sensitized animals].

Studies of phagocytic cells of the abdominal cavity in rats in experimental candidosis were carried out. The processes of interaction between phagocytic cells and the pathogene in intact animals and after the vaccination, were analysed. It was established that in parallel with an increase in the functional activity, phagocytes changed morphologically and cytochemically: their nucleo-cytoplasmatic ratio drastically dropped, motility increased, as well as the activity of hydrolytic enzymes. In the sensitized macrophages there appeared activity of alkaline phophotase (in intact macrophages in rats this enzyme was not revealed). Particular attention was paid to the activation of the hexose-monophosphate cycle regulating phagocytosis, and to accumulation in neutrophiles of bactericidal free aldehydes. Enzymatic characteristics and differences between peritoneal macrophages and neutrophilic leucocytes were shown.