抗癌抗生素链脲佐菌素的2-氯乙基类似物氯脲佐菌素的合成。 - Suppr

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Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin.

作者信息

Johnston T P, McCaleb G S, Montgomery J A

出版信息

J Med Chem. 1975 Jan;18(1):104-6. doi: 10.1021/jm00235a023.

DOI:10.1021/jm00235a023

PMID:122802

Abstract

摘要

相似文献

Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin.抗癌抗生素链脲佐菌素的2-氯乙基类似物氯脲佐菌素的合成。

J Med Chem. 1975 Jan;18(1):104-6. doi: 10.1021/jm00235a023.

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New streptozotocin analogs with improved antileukemic activity.

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L-Chlorozotocin.

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Pharmacology of chlorozotocin Nsc-178248), a new nitrosourea antitumor agent.新型亚硝基脲类抗肿瘤药物氯脲霉素（Nsc - 178248）的药理学

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Alkyl streptozotocin analogues with improved biological activities.

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A comparison of the biological and biochemical properties of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose.

Cancer Res. 1978 Jan;38(1):65-8.

Preclinical and clinical studies on chlorozotocin, a new nitrosourea with decreased bone marrow toxicity.关于氯脲霉素（一种骨髓毒性降低的新型亚硝基脲）的临床前和临床研究。

Recent Results Cancer Res. 1980;70:83-9. doi: 10.1007/978-3-642-81392-4_9.

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Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors.

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Cytostatic action of two nitrosoureas derived from cysteamine.两种源自半胱胺的亚硝基脲的细胞生长抑制作用。

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DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds.抗肿瘤和致癌性N-亚硝基化合物导致的DNA加合物与DNA损伤

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Comparative pharmacology of three new nitrosourea analogues: RFCNU, RPCNU, and chlorozotocin. I. Oncostatic effects in mice.三种新型亚硝基脲类似物：RFCNU、RPCNU和氯脲霉素的比较药理学。I. 对小鼠的抑癌作用

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Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.将四种新合成的2-氯乙基亚硝脲与卡莫司汀、洛莫司汀、司莫司汀、链脲佐菌素和羟乙基亚硝脲在晚期大鼠白血病L 5222中进行比较研究。

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Chlorozotocin. Mechanism of reduced bone marrow toxicity in mice.氯脲霉素。小鼠骨髓毒性降低的机制。

J Clin Invest. 1979 Oct;64(4):1103-11. doi: 10.1172/JCI109549.

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