Zeller W J, Eisenbrand G, Fiebig H H
J Cancer Res Clin Oncol. 1979 Sep;95(1):43-9. doi: 10.1007/BF00411108.
The newly synthesized nitrosoureas 1-(2-chloroethyl)-1-nitroso-3-(methylenecarboxamido)-urea (Acetamido-CNU), 1-(2-chloroethyl)-1-nitroso-3-(4-morpholino)-urea (Morpholino-CNU), 1-(2-chloroethyl)-1-nitroso-3-(1-piperidino)-urea (Piperidino-CNU), and 2-[3-(2-chloroethyl)-3-nitrosoureido]-ethylmethanesulfonate (Ethylmethanesulfonato-CNU) were compared in their chemotherapeutic activity against preterminal rat leukemia L 5222 with BCNU, CCNU, MeCCNU, Chlorozotocin, and Hydroxyethyl-CNU. With respect to the dose range effecting a median survival time of more than 90 days, MeCCNU was superior to the other substances. Chlorozotocin, on the other hand, was the only substance which achieved no cures in this experimental arrangement. From the four newly introduced substances the water-soluble substances Acetamido-CNU and Morpholino-CNU were approximately comparable to CCNU with regard to the dose range effecting a median survival time of greater than 90 days. Piperidino-CNU and Ethylmethanesulfonato-CNU also effected cures; however, only Piperidino-CNU in one dosage effected a median survival time of greater than 90 days.
将新合成的亚硝基脲类化合物1-(2-氯乙基)-1-亚硝基-3-(亚甲基甲酰胺基)脲（乙酰氨基-CCNU）、1-(2-氯乙基)-1-亚硝基-3-(4-吗啉代)脲（吗啉代-CCNU）、1-(2-氯乙基)-1-亚硝基-3-(1-哌啶基)脲（哌啶基-CCNU）和2-[3-(2-氯乙基)-3-亚硝基脲基]乙烷磺酸盐（乙烷磺酸盐-CCNU）与卡莫司汀（BCNU）、洛莫司汀（CCNU）、司莫司汀（MeCCNU）、氯脲霉素和羟乙基亚硝基脲在对终末期前大鼠白血病L 5222的化疗活性方面进行了比较。就影响中位生存时间超过90天的剂量范围而言，MeCCNU优于其他物质。另一方面，氯脲霉素是在这种实验安排中唯一未实现治愈的物质。从四种新引入的物质来看，水溶性物质乙酰氨基-CCNU和吗啉代-CCNU在影响中位生存时间大于90天的剂量范围方面与CCNU大致相当。哌啶基-CCNU和乙烷磺酸盐-CCNU也实现了治愈；然而，只有一种剂量的哌啶基-CCNU实现了中位生存时间大于90天。
