谷胱甘肽S-转移酶M1基因缺失与子宫内膜异位症遗传易感性的关联
[Association between glutathione S-transferase M1 gene deletion and genetic susceptibility to endometriosis].
作者信息
Peng Dong-xian, He Yuan-li, Qiu Li-wen, Yang Fang, Lin Jing-ming
机构信息
Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2003 May;23(5):458-9, 462.
OBJECTIVE
To evaluate the possible association of the glutathione S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometriosis in women of Han nationality in Guangdong Province.
METHODS
Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometriosis and 80 controls (surgical patients for gynecological problems other than endometriosis).
RESULTS
The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a significant difference between the endometriotic cohort and the control group (X(2)=6.03, P < 0.05). Individuals with GSTM1 null genotype were exposed to risks for endometriosis 2.24 times that of subjects without these genotypes OR=2.24, 95% CI=1.17-4.27 .
CONCLUSION
GSTM1 gene deletion might bea risk factor for endometriosis in women of Han nationality who are native residents in Guangdong Province.
目的
评估谷胱甘肽S - 转移酶M1（GSTM1）基因多态性与广东省汉族女性子宫内膜异位症易感性之间的可能关联。
方法
采用聚合酶链反应鉴定76例子宫内膜异位症患者和80例对照者（因非子宫内膜异位症的妇科问题接受手术的患者）的GSTM1基因型。
结果
子宫内膜异位症患者和对照者中GSTM1无效基因型的频率分别为65.8%和46.3%，子宫内膜异位症队列与对照组之间存在显著差异（X(2)=6.03，P < 0.05）。GSTM1无效基因型个体患子宫内膜异位症的风险是无这些基因型个体的2.24倍（OR = 2.24，95% CI = 1.17 - 4.27）。
结论
GSTM1基因缺失可能是广东省本地汉族女性患子宫内膜异位症的一个风险因素。
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