Bogdanski Denise, Köller Manfred, Müller Dietmar, Muhr Gert, Bram Martin, Buchkremer Hans Peter, Stöver Detlev, Choi Jongsik, Epple Matthias
Department of Surgery, BG Kliniken Bergmannsheil, University of Bochum, Germany.
Biomaterials. 2002 Dec;23(23):4549-55. doi: 10.1016/s0142-9612(02)00200-4.
The biocompatibility of nickel-titanium alloys was investigated by single-culture experiments on functionally graded samples with a stepwise change in composition from pure nickel to pure titanium, including an Ni-Ti shape memory alloy for a 50:50 mixture. This approach permitted a considerable decrease of experimental resources by simultaneously studying a full variation of composition. The results indicate a good biocompatibility for a nickel content up to about 50%. The cells used in the biocompatibility studies comprised osteoblast-like osteosarcoma cells (SAOS-2, MG-63), primary human osteoblasts (HOB), and murine fibroblasts (3T3).
通过对成分从纯镍到纯钛逐步变化的功能梯度样品进行单培养实验，研究了镍钛合金的生物相容性，其中包括一种50:50混合物的镍钛形状记忆合金。这种方法通过同时研究成分的全变化，大幅减少了实验资源。结果表明，镍含量高达约50%时具有良好的生物相容性。生物相容性研究中使用的细胞包括成骨样骨肉瘤细胞（SAOS-2、MG-63）、原代人成骨细胞（HOB）和小鼠成纤维细胞（3T3）。
