钠钾激活的ATP酶。醛固酮的一个可能靶点。
Sodium- and potassium-activated ATPase. A possible target of aldosterone.
作者信息
Schmidt U, Schmid J, Schmid H, Dubach U C
出版信息
J Clin Invest. 1975 Mar;55(3):655-60. doi: 10.1172/JCI107973.
Abstract
Na-K-ATPase activity was measured with an ultramicromethod in single portions of the proximal and distal convolution and of the thick ascending limb of Henle from adrenalectomized rats and after treatment with 5 mug aldosterone per 100 g body wt. The activity in all tubular structures returned to normal within 1 h after injection. This rapid activation of Na-K-ATPase induced by hormone was completely prevented by actinomycin D and cycloheximide. It appears that this aldosterone effect on Na-K-ATPase requires an intact protein synthetic process.
摘要
采用超微量法测定了肾上腺切除大鼠以及每100克体重注射5微克醛固酮处理后的大鼠近端和远端曲管及髓袢升支粗段单个部分的钠钾ATP酶活性。注射后1小时内，所有肾小管结构中的活性均恢复正常。放线菌素D和环己酰亚胺可完全阻止激素诱导的钠钾ATP酶的这种快速激活。看来这种醛固酮对钠钾ATP酶的作用需要完整的蛋白质合成过程。
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