Pedersen P V
J Pharm Sci. 1978 Feb;67(2):187-91. doi: 10.1002/jps.2600670216.
A general treatment of linear pharmacokinetics that enables equations to be obtained simply for all linear compartmental models, with input in one or more compartments, is presented. Two approaches are described: one based on a full Laplace transformation and one that avoids transformation of the input functions and the use of convolution integrals. The latter approach is of particular interest when dealing with complex input functions not having a simple Laplace transform. The concept of acceptor and donor subsystems is introduced. It is demonstrated that disposition in certain models may be simplified and analyzed in terms of disposition in subsystems of simpler composition. The treatment presented is illustrated with several examples.
本文提出了一种线性药代动力学的通用处理方法，该方法能够简单地获得适用于所有线性房室模型的方程，这些模型的输入可以在一个或多个房室中。文中描述了两种方法：一种基于完全拉普拉斯变换，另一种则避免了输入函数的变换以及卷积积分的使用。当处理没有简单拉普拉斯变换的复杂输入函数时，后一种方法特别有用。文中引入了受体和供体子系统的概念。结果表明，某些模型中的处置情况可以根据组成更简单的子系统中的处置情况进行简化和分析。文中通过几个例子说明了所提出的处理方法。
