Wolf M, Heinzel G, Koss F W, Bozler G
Arzneimittelforschung. 1977;27(4a):900-4.
The method of Laplace transformation is used to obtain the integral of linear differential equations for pharmacokinetic models. A general solution uniform in structure for all types of models (mammillary, catenary, mixed) was established. Choice of one more application compartments, of kinetics describing the input procedure and of elimination pathways is free.
采用拉普拉斯变换方法来求解药代动力学模型线性微分方程的积分。建立了适用于所有类型模型(乳突状、链状、混合型)的结构统一的通解。对于更多应用隔室、描述输入过程的动力学以及消除途径的选择是自由的。