Katenkamp D, Stiller D
Exp Pathol (Jena). 1975;11(3-4):190-206. doi: 10.1016/s0014-4908(75)80060-3.
In continuation of our investigations on methylcholanthrene-induced rat sarcomas, in analogy to light microscopical results, various cytological differentiations could be demonstrated by the electron microscope. Some tumour cells are comparable to the cellular counterpart in normal connective tissue, whereas most of the tumour cells show various series of cytological traits of different types of normal connective tissue cells simultaneously. The vast majority of tumour cells exhibited characteristics of fibroblasts and histiocytes coincidently. However, classical fibroblasts and histiocytes were seldom present. One part of the tumour cells showed structural features as known from so-called myofibroblasts and smooth muscles cells. Furthermore, vasoformative potencies of sarcomas with imitation of endothelial and pericytic cells must be emphasized. With respect to the histogenesis of these sarcomas possible origin from the microvasculature is discussed.
在我们对甲基胆蒽诱导的大鼠肉瘤的研究中，与光学显微镜观察结果类似，电子显微镜显示出各种细胞分化。一些肿瘤细胞与正常结缔组织中的细胞类似，而大多数肿瘤细胞同时表现出不同类型正常结缔组织细胞的一系列细胞学特征。绝大多数肿瘤细胞同时表现出成纤维细胞和组织细胞的特征。然而，典型的成纤维细胞和组织细胞很少出现。一部分肿瘤细胞呈现出所谓肌成纤维细胞和平滑肌细胞的结构特征。此外，必须强调肉瘤具有模仿内皮细胞和周细胞的血管形成能力。关于这些肉瘤的组织发生，讨论了其可能起源于微脉管系统。
