Nishimura Shinichi, Matsunaga Shigeki, Shibazaki Mitsuyoshi, Suzuki Kenichi, Harada Nobuyuki, Naoki Hideo, Fusetani Nobuhiro
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Japan.
J Nat Prod. 2002 Sep;65(9):1353-6. doi: 10.1021/np020080f.
Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1-3 inhibited GGTase I from Candida albicans with IC(50) values of 1.9-7.3 microM.
从海洋海绵皮质扁海绵（Petrosia corticata）中分离出了两种新的聚乙炔酸，即皮质扁海绵酸D（2）和E（3），以及已知的皮质扁海绵酸A（1），它们都是I型香叶基香叶基转移酶（GGTase I）抑制剂。通过光谱和化学方法阐明了它们的结构。化合物1 - 3对白色念珠菌的GGTase I具有抑制作用，IC（50）值为1.9 - 7.3微摩尔。
