来自海洋海绵Petrosia sp.的新型聚乙炔的结构解析与细胞毒性评估

Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp.

作者信息

Juan Yung-Shun, Lee Chien-Chih, Tsao Chia-Wei, Lu Mei-Chin, El-Shazly Mohamed, Shih Huei-Chuan, Chen Yu-Cheng, Wu Yang-Chang, Su Jui-Hsin

机构信息

Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan.

Epigenome Research Center, Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan.

出版信息

Int J Mol Sci. 2014 Sep 18;15(9):16511-21. doi: 10.3390/ijms150916511.

DOI:10.3390/ijms150916511

PMID:25238415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4200862/

Abstract

The sponge Petrosia sp. yielded five polyacetylenic compounds (1-5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1-5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.

摘要

海绵Petrosia sp.产生了五种聚乙炔类化合物（1-5），包括两种新的聚乙炔类化合物，海绵炔A（1）和海绵炔B（2）。通过详细的光谱分析以及与相关已知类似物的物理和光谱数据进行比较，阐明了这些化合物的结构。化合物1-5对一组有限的癌细胞系表现出显著的细胞毒性活性。