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评估一种联合检测策略，用于检测卡波西肉瘤患者、无症状人疱疹病毒8型（HHV-8）感染者以及HHV-8感染低风险人群中的HHV-8抗体。

Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection.

作者信息

Casper Corey, Krantz Elizabeth, Taylor Heather, Dalessio Julie, Carrell David, Wald Anna, Corey Lawrence, Ashley Rhoda

机构信息

Department of Medicine, Virology Research Clinic, University of Washington School of Medicine, Box 359928, Seattle, WA 98195, USA.

出版信息

J Clin Microbiol. 2002 Oct;40(10):3822-5. doi: 10.1128/JCM.40.10.3822-3825.2002.

DOI:10.1128/JCM.40.10.3822-3825.2002
PMID:12354890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130660/
Abstract

The performance of a human herpesvirus 8 (HHV-8) enzyme immunoassay (EIA) and selective subsequent use of an HHV-8 immunofluorescence assay (IFA) was tested in persons unlikely to be infected with HHV-8 and those who had HHV-8 detected in their saliva. The IFA was performed on samples within a range of EIA optical densities (0.15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%.

摘要

在不太可能感染人类疱疹病毒8型（HHV-8）的人群以及唾液中检测到HHV-8的人群中，对HHV-8酶免疫测定（EIA）的性能以及随后选择性使用HHV-8免疫荧光测定（IFA）进行了测试。IFA是对EIA光密度范围在0.15至0.35之间的样本进行检测的，在此范围内，HHV-8感染个体和未感染个体之间存在相当大的重叠。该检测策略的灵敏度为88%，特异性为97%。

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