Herrero Inmaculada A, Rouse Mark S, Piper Kerryl E, Alyaseen Samer A, Steckelberg James M, Patel Robin
Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
J Clin Microbiol. 2002 Oct;40(10):3848-50. doi: 10.1128/JCM.40.10.3848-3850.2002.
Studies that detected an association between Streptococcus bovis endocarditis and colon carcinoma have not taken into account the recently identified genetic diversity among organisms historically classified as S. bovis. With near full-length 16S ribosomal DNA sequence analysis, organisms cultured from the blood of endocarditis patients at the Mayo Clinic from 1975 to 1985 and previously identified as S. bovis or streptococcus group D nonenterococci were shown to represent S. bovis biotypes I (11 isolates) and II/2 (1 isolate), S. salivarius (1 isolate), and S. macedonicus (1 isolate). Two of the S. bovis biotype I cases were associated with colon cancer. Whether S. bovis biotype II or other organisms closely related to and historically identified as S. bovis (e.g., S. macedonicus) are associated with malignant (or premalignant) colon lesions in humans remains to be definitively determined.
那些检测到牛链球菌心内膜炎与结肠癌之间存在关联的研究，并未考虑到近期在历史上被归类为牛链球菌的生物体中发现的基因多样性。通过近乎全长的16S核糖体DNA序列分析，对1975年至1985年在梅奥诊所从心内膜炎患者血液中培养出的、先前被鉴定为牛链球菌或D群非肠球菌的生物体进行分析，结果显示它们分别代表牛链球菌生物I型（11株分离菌）和II/2型（1株分离菌）、唾液链球菌（1株分离菌）以及马其顿链球菌（1株分离菌）。两例牛链球菌生物I型病例与结肠癌有关。牛链球菌生物II型或其他与历史上被鉴定为牛链球菌密切相关的生物体（如马其顿链球菌）是否与人类的恶性（或癌前）结肠病变有关，仍有待明确确定。
