κ链基因座的差异可及性在等位基因排斥中起作用。
Differential accessibility at the kappa chain locus plays a role in allelic exclusion.
作者信息
Goldmit Maya, Schlissel Mark, Cedar Howard, Bergman Yehudit
机构信息
The Hubert H.Humphrey Center for Experimental Medicine and Cancer Research, Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.
出版信息
EMBO J. 2002 Oct 1;21(19):5255-61. doi: 10.1093/emboj/cdf518.
Abstract
Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion.
摘要
免疫系统中的基因重排总是先于DNA去甲基化和染色质可及性增加。利用一个阻止内源性免疫球蛋白κ基因座重排的模型系统，我们证明这些表观遗传和染色质变化实际上在一个等位基因上发生的概率高于另一个等位基因。可能正是这个过程与反馈抑制一起，构成了等位基因排斥的基础。
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