免疫系统中重组的表观遗传控制。
Epigenetic control of recombination in the immune system.
机构信息
Department of Developmental Biology and Cancer Research, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.
出版信息
Semin Immunol. 2010 Dec;22(6):323-9. doi: 10.1016/j.smim.2010.07.003. Epub 2010 Sep 15.
Abstract
Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.
摘要
免疫受体基因的表达受一系列发育事件的调控，这些事件以基因座、细胞类型、阶段和等位基因特异性的方式改变其可及性。这是通过许多不同的分子机制的程序化组合来实现的，包括全区域复制时间、核定位变化、染色质收缩、组蛋白修饰、核小体定位和 DNA 甲基化。这些方式最终通过控制受体基因座与重组机制之间的空间相互作用来发挥作用。
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