[短期禁食对大鼠肝脏溶酶体的影响，生化研究（初步报告）]
[Effect of short-term fasting on liver lysosomes in rats, biochemical studies (preliminary report)].
作者信息
Apostolov I, Krustev L, Stefanova M, Pramatarova V
出版信息
Probl Khig. 1975;1:149-53.
The total activity of four lysosome enzymes--acid phosphatase, beta-glucuronidase, alpha-glucosidase and beta-N-acetylglucosaminidase--is studied in liver homogenate at 2, 6, 24 and 48 hours after the last meal in rats, previously sustained on a single-daily-feeding regimen. In addition, the free activity (percentage of the total) of the latter enzyme and its activity in the serum as well are investigated. A rise of the total activity of the first three enzymes is recorded within 48 hours after the beginning of starvation. The free activity of beta-N-acetylglucosaminidase shows an increase at 48 hours, while its activity in the serum--as early as 24 hours. The changes described above are interpreted as an expression of lysosome membrane permeability enhancement under fasting conditions.
对先前采用每日单餐喂养方案的大鼠，在最后一次进食后2、6、24和48小时，研究其肝脏匀浆中四种溶酶体酶——酸性磷酸酶、β - 葡萄糖醛酸酶、α - 葡萄糖苷酶和β - N - 乙酰氨基葡萄糖苷酶——的总活性。此外，还研究了后一种酶的游离活性（占总活性的百分比）及其在血清中的活性。饥饿开始后48小时内，记录到前三种酶的总活性升高。β - N - 乙酰氨基葡萄糖苷酶的游离活性在48小时时增加，而其在血清中的活性——早在24小时时就增加。上述变化被解释为禁食条件下溶酶体膜通透性增强的表现。
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