Kim Seong-Gi, Ogawa Seiji
Department of Neurobiology, University of Pittsburgh, E-1140 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA.
Curr Opin Neurobiol. 2002 Oct;12(5):607-15. doi: 10.1016/s0959-4388(02)00355-0.
Non-invasive functional magnetic resonance imaging (fMRI) has opened a unique window into human and animal brain function, with a spatial resolution of a few millimeters and a temporal resolution of a few seconds. To further improve the current technical limitations of fMRI, various post-processing and data acquisition schemes were developed. Improved fMRI methods include variations of a conventional fMRI technique, mapping a single physiological parameter such as cerebral blood flow or cerebral blood volume, and direct mapping of neural activity. Advances in fMRI techniques allow scientists to map submillimeter columnar and laminar functional structures and to detect tens of millisecond neural activity in certain specific tasks.
无创功能磁共振成像(fMRI)为研究人类和动物的脑功能打开了一扇独特的窗口,其空间分辨率可达几毫米,时间分辨率为几秒。为了进一步改善fMRI当前的技术局限性,人们开发了各种后处理和数据采集方案。改进后的fMRI方法包括传统fMRI技术的变体、绘制诸如脑血流量或脑血容量等单一生理参数,以及直接绘制神经活动。fMRI技术的进步使科学家能够绘制亚毫米级的柱状和层状功能结构,并在某些特定任务中检测几十毫秒的神经活动。