Abdel-Ghani Nour T, Shoukry Adel F, Hussein Salwa H
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
J Pharm Biomed Anal. 2002 Oct 15;30(3):601-11. doi: 10.1016/s0731-7085(02)00348-5.
New amantadine (Am) ion selective plastic membrane electrodes of both conventional and coated graphite types based on the ion-pair of amantadinium tetraphenylborate (Am-TPB) ion-pair are prepared. The conventional type electrode was fully characterized in terms of membrane composition, life span, pH, ionic strength and temperature. It was applied to potentiometric determination of amantadine in pure state and pharmaceutical preparation under batch and flow injection conditions. The selectivity of the electrode toward a large number of inorganic cations, sugars and amino acids was tested. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductimetrically.
基于金刚烷四苯基硼酸盐（Am-TPB）离子对，制备了新型金刚烷胺（Am）常规型和涂覆石墨型离子选择性塑料膜电极。对常规型电极在膜组成、寿命、pH值、离子强度和温度方面进行了全面表征。将其应用于在批量和流动注射条件下对纯态和药物制剂中金刚烷胺的电位测定。测试了该电极对大量无机阳离子、糖类和氨基酸的选择性。通过电导法测定了离子对的溶度积以及导致离子对形成的沉淀反应的形成常数。
