Ibrahim Hosny, Issa Yousry M, Abu-Shawish Hazem M
Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.
J Pharm Biomed Anal. 2005 Jan 4;36(5):1053-61. doi: 10.1016/j.jpba.2004.08.032.
Four PVC membrane electrodes for the determination of mebeverine hydrochloride (MvCl) were fabricated and fully characterized in terms of composition, life span, usable pH range, working concentration range and temperature. The membranes of these electrodes consist of mebeverinium-silicotungstate (Mv-ST), silicomolybdate (Mv-SM), phosphotungstate (Mv-PT), or phosphomolybdate (Mv-PM) ion-associations dispersed in PVC matrix with dibutyl phthalate plasticizer. The electrodes showed near-Nernstian response over the concentration range of 4.0 x 10(-6) to 1.0 x 10(-2)M MvCl and were applied to the potentiometric determination of mebeverinium ion in pharmaceutical preparations, serum and urine in steady state and flow injection (FI) conditions with average recoveries of 96.4-102 % and relative standard deviations of 0.132-1.86%. The electrodes exhibit good selectivity for MvCl with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The sensitivities of these electrodes are high enough to measure as low as 1.86 microg/ml of MvCl which permit the determination of the Ksp values of the ion-associates used. The proposed potentiometric methods offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and colored sample solutions.
制备了用于测定盐酸美贝维林（MvCl）的四个PVC膜电极，并在组成、寿命、可用pH范围、工作浓度范围和温度方面进行了全面表征。这些电极的膜由分散在含有邻苯二甲酸二丁酯增塑剂的PVC基质中的美贝维铵-硅钨酸盐（Mv-ST）、硅钼酸盐（Mv-SM）、磷钨酸盐（Mv-PT）或磷钼酸盐（Mv-PM）离子缔合物组成。在4.0×10（-6）至1.0×10（-2）M MvCl的浓度范围内，电极显示出近能斯特响应，并应用于药物制剂、血清和尿液中稳态和流动注射（FI）条件下美贝维铵离子的电位测定，平均回收率为96.4 - 102%，相对标准偏差为0.132 - 1.86%。相对于大量无机阳离子、有机阳离子、糖类和氨基酸，电极对MvCl表现出良好的选择性。这些电极的灵敏度足够高，能够测量低至1.86μg/ml的MvCl，这使得能够测定所用离子缔合物的Ksp值。所提出的电位法具有简单、准确、自动化可行性以及适用于浑浊和有色样品溶液的优点。
