Abdel-Ghani Nour T, Hussein Salwa H
Faculty of Science, Chemistry Department, Cairo University, Giza, Egypt.
Farmaco. 2003 Aug;58(8):581-9. doi: 10.1016/S0014-827X(03)00045-4.
New ambroxol (Amb) ion selective plastic membrane electrodes of both conventional and coated graphite types based on the ion-pair of ambroxolium tetraphenylborate (Amb-TPB) ion-pair are prepared. The conventional type electrode was fully characterized in terms of membrane composition, life span, pH, ionic strength and temperature. It was applied to potentiometric determination of ambroxol in pure solutions and pharmaceutical preparations under batch and flow injection conditions. The potentiometric determination was used in the determination of ambroxol in muco syrup in four batches of different expiry dates, also the amounts of ambroxol released after 1, 8 and 16 h from the muco sustained release type (S.R.) capsules were also assayed. The selectivity of the electrode toward a large number of excipient like inorganic cations, sugars and amino acids was tested. The solubility product of the ion-pair and the formation constant of the precipitation reaction leading to the ion-pair formation were determined conductimetrically.
基于氨溴索四苯基硼酸盐（Amb-TPB）离子对，制备了新型氨溴索（Amb）常规型和涂覆石墨型离子选择性塑料膜电极。对常规型电极在膜组成、寿命、pH、离子强度和温度方面进行了全面表征。将其应用于在批量和流动注射条件下对纯溶液和药物制剂中氨溴索的电位测定。电位测定法用于测定四批不同有效期的黏液糖浆中的氨溴索，还测定了黏液缓释型（S.R.）胶囊在1、8和16小时后释放的氨溴索量。测试了该电极对大量赋形剂（如无机阳离子、糖和氨基酸）的选择性。通过电导法测定了离子对的溶度积和导致离子对形成的沉淀反应的形成常数。
