Kamireddy Rajani, Kavuri Suchitra, Devi Sri, Vemula Harathi, Chandana Devi, Harinarayanan Salini, James Reena, Rao Anjali
Department of Biochemistry, Kasturba Medical College, Manipal-576 119, Karnataka, India.
Clin Chim Acta. 2002 Nov;325(1-2):147-50. doi: 10.1016/s0009-8981(02)00294-2.
Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy.
The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients.
Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde.
Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.
肾病综合征（NS）对儿童来说是一种应激状态，氧化损伤也会影响这些患者对治疗的反应。
本研究在肾病综合征复发期和缓解期的儿童以及10名年龄和性别匹配的健康志愿者中进行。分析了对照组和患者组的红细胞谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和丙二醛（MDA）浓度，以及血浆铜蓝蛋白（CP）和维生素E浓度。
与对照组相比，两组的红细胞超氧化物歧化酶浓度均显著升高。肾病综合征缓解期的红细胞谷胱甘肽以及两组的血浆维生素E浓度均显著降低。缓解期患者的血浆铜蓝蛋白显著升高。然而，红细胞丙二醛浓度未观察到显著变化。
因此，抗氧化剂浓度变化显著，表明在这种情况下存在一种补偿机制来应对增加的促氧化状态。
