Asako Yoshiko, Saito Akemi, Yasueda Hiroshi, Kawaguchi Hiroshi, Akiyama Kazuo, Endo Masahiro, Onishi Yoshimi, Takesako Kazutoh
Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital.
Arerugi. 2002 Aug;51(8):615-21.
We analyzed the reactivities of a series of purified allergens from Candida albicans (C. albicans) and Malassezia furfur (M. furfur) with IgE antibodies in sera from patients with atopic dermatitis. We compared the specific IgE antibody levels to manganese superoxide dismutase (Mn SOD), cyclophilin, enolase, secretory aspartic protease (SAP 2) and type A mannan from C. albicans and Mn SOD, cyclophilin and Mal f 2 from M. furfur in 21 sera from patients with atopic dermatitis and 20 sera from patients with asthma without atopic dermatitis. The prevalence of IgE antibodies and the mean IgE antibody levels to all of the allergens tested were higher among patients with atopic dermatitis than among those with asthma without atopic dermatitis. More than 50% of patients with atopic dermatitis were IgE antibody-positive to Mn SOD, cyclophilin and type A mannan from C. albicans, and Mn SOD and cyclophilin from M. furfur. The availability of these purified allergens will facilitate studies on the contribution of fungal allergens to the development of atopic dermatitis.
我们分析了一系列来自白色念珠菌（白色假丝酵母）和糠秕马拉色菌的纯化变应原与特应性皮炎患者血清中IgE抗体的反应性。我们比较了21份特应性皮炎患者血清和20份无特应性皮炎的哮喘患者血清中针对白色念珠菌的锰超氧化物歧化酶（Mn SOD）、亲环蛋白、烯醇酶、分泌型天冬氨酸蛋白酶（SAP 2）和A型甘露聚糖以及糠秕马拉色菌的Mn SOD、亲环蛋白和Mal f 2的特异性IgE抗体水平。特应性皮炎患者中针对所有测试变应原的IgE抗体患病率和平均IgE抗体水平均高于无特应性皮炎的哮喘患者。超过50%的特应性皮炎患者对白色念珠菌的Mn SOD、亲环蛋白和A型甘露聚糖以及糠秕马拉色菌的Mn SOD和亲环蛋白呈IgE抗体阳性。这些纯化变应原的可得性将有助于研究真菌变应原在特应性皮炎发病中的作用。
