Carugo Oliviero, Pongor Sandor
General Chemistry Department, Pavia University, viale Taramelli 12, 27100 Pavia, Italy.
Curr Protein Pept Sci. 2002 Aug;3(4):441-9. doi: 10.2174/1389203023380530.
Quantitation of protein 3-D structure similarity is crucial in such fields as evolutionary studies, structural modeling and prediction of biological function. There are various approaches, many of which are tailored to specific problems. This review summarizes the recent developments in this field with particular interest in two main areas: i) improvements to and statistical interpretation of the root-man-square distance between equivalent atoms, rmsd; and ii) methods of protein structural classification based on geometrical features. Special attention is given to fast methods capable of analyzing large structural databases.
蛋白质三维结构相似性的定量在进化研究、结构建模和生物功能预测等领域至关重要。有多种方法，其中许多是针对特定问题量身定制的。本综述总结了该领域的最新进展，特别关注两个主要方面：i）等效原子之间的均方根距离（rmsd）的改进及统计解释；ii）基于几何特征的蛋白质结构分类方法。特别关注能够分析大型结构数据库的快速方法。
