Bacchi C J, Yarlett N
Haskins Laboratories and Department of Biology, Pace University, 41 Park Row, New York, NY 10038, USA.
Mini Rev Med Chem. 2002 Dec;2(6):553-63. doi: 10.2174/1389557023405549.
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
多胺是所有生物体必需的细胞成分。本综述重点介绍了原生动物寄生虫（布氏锥虫、克氏锥虫、微小隐孢子虫和阴道毛滴虫）与其哺乳动物宿主在多胺合成、降解和相互转化方面的重要差异。方法包括开发针对多胺相互转化的单取代和二取代多胺类似物，以及对合成酶和相关途径进行更传统的靶向研究。
