Newbold Retha R, Moore Alicia B, Dixon Darlene
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Toxicol Pathol. 2002 Sep-Oct;30(5):611-6. doi: 10.1080/01926230290105839.
Experimental animal and clinical studies have well established the association of prenatal exposure to diethylstilbestrol (DES) and the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia. Overwhelmingly, the focus has been on DES-induced epithelial lesions, particularly vaginal adenosis and adenocarcinoma; however, uterine smooth muscle cells are also recognized as cellular targets of DES. This descriptive report characterizes uterine leiomyomas that occur in outbred CD-1 mice following exposure to DES prenatally on days 9 to 16 of gestation or on neonatal days 1 to 5. These DES-induced uterine leiomyomas have typical histomorphologic, and some immunohistochemical characteristics of spontaneously occurring uterine smooth muscle tumors of B6C3F1 mice previously described in our laboratory, and they are also similar to uterine leiomyomas (fibroids) commonly observed in premenopausal women.
实验动物和临床研究已充分证实，产前接触己烯雌酚（DES）与随后生殖道异常的发生有关，包括生殖结局不良和肿瘤形成。绝大多数情况下，研究重点一直是DES诱导的上皮病变，尤其是阴道腺病和腺癌；然而，子宫平滑肌细胞也被认为是DES的细胞靶点。本描述性报告对妊娠第9至16天或新生第1至5天产前接触DES的远交系CD-1小鼠发生的子宫平滑肌瘤进行了特征描述。这些DES诱导的子宫平滑肌瘤具有我们实验室先前描述的B6C3F1小鼠自发发生的子宫平滑肌肿瘤的典型组织形态学特征和一些免疫组化特征，并且它们也类似于绝经前女性中常见的子宫平滑肌瘤（纤维瘤）。
