Morris-Jones R
St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
Clin Exp Dermatol. 2002 Sep;27(6):427-31. doi: 10.1046/j.1365-2230.2002.01087.x.
Sporotrichosis is a cutaneous fungal infection with a global distribution. The disease has several clinical forms, primarily cutaneous with associated lymphadenopathy. However, dissemination to osteoarticular structures and viscera may occur, both in healthy and immunosuppressed individuals; such disseminated forms usually follow spread after inhalation of fungal spores. Cutaneous infection is usually associated with trauma during the course of outdoor work, and treatment is required for the majority of patients. Potassium iodide (the treatment of choice in endemic areas) is an effective and inexpensive therapy; however, its adverse effects and complicated dosage regimen often weigh against its use in developed countries, where itraconazole is the antimycotic of choice.
孢子丝菌病是一种全球分布的皮肤真菌感染。该疾病有多种临床形式,主要为伴有相关淋巴结病的皮肤型。然而,在健康个体和免疫抑制个体中,均可发生播散至骨关节结构和内脏的情况;此类播散型通常是在吸入真菌孢子后发生传播。皮肤感染通常与户外工作过程中的创伤有关,大多数患者需要进行治疗。碘化钾(流行地区的首选治疗药物)是一种有效且廉价的疗法;然而,其不良反应和复杂的给药方案常常使其在发达国家的使用受到限制,在这些国家,伊曲康唑是抗真菌的首选药物。