TOR信号复合物的鉴定：细胞生长引擎的更多TORC

Identification of TOR signaling complexes: more TORC for the cell growth engine.

作者信息

Abraham Robert T

机构信息

Program in Signal Transduction Research, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Cell. 2002 Oct 4;111(1):9-12. doi: 10.1016/s0092-8674(02)01009-7.

DOI:10.1016/s0092-8674(02)01009-7

PMID:12372295

Abstract

The Target of Rapamycin (TOR) proteins function in signaling pathways that promote protein synthesis and cell growth. In yeast, TOR signaling is regulated by nutrient availability, whereas in metazoan cells TOR activities may be controlled by both nutrients and growth factors. The recent identification of novel TOR-interacting proteins has provided crucial insights into TOR regulation and function.

摘要

雷帕霉素靶蛋白（TOR）在促进蛋白质合成和细胞生长的信号通路中发挥作用。在酵母中，TOR信号传导受营养物质可用性的调节，而在后生动物细胞中，TOR活性可能受营养物质和生长因子两者的控制。最近对新型TOR相互作用蛋白的鉴定为TOR的调节和功能提供了关键见解。