酵母中的TOR信号通路与生长调控 - Suppr

The TOR signalling pathway and growth control in yeast.

作者信息

Hall M N

机构信息

Department of Biochemistry, Biozentrum, University of Basel, Switzerland.

出版信息

Biochem Soc Trans. 1996 Feb;24(1):234-9. doi: 10.1042/bst0240234.

DOI:10.1042/bst0240234

PMID:8674674

Abstract

摘要

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The TOR signalling pathway and growth control in yeast.

Biochem Soc Trans. 1996 Feb;24(1):234-9. doi: 10.1042/bst0240234.

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

J Biol Chem. 1994 Dec 23;269(51):32027-30.

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin.

Cell. 1995 Jul 14;82(1):121-30. doi: 10.1016/0092-8674(95)90058-6.

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.

J Biol Chem. 1995 Jan 13;270(2):815-22. doi: 10.1074/jbc.270.2.815.

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

J Biol Chem. 1995 Nov 17;270(46):27531-7. doi: 10.1074/jbc.270.46.27531.

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

Cell. 1994 Jul 15;78(1):35-43. doi: 10.1016/0092-8674(94)90570-3.

Control of translation by the target of rapamycin proteins.

Prog Mol Subcell Biol. 2001;27:143-74. doi: 10.1007/978-3-662-09889-9_6.

Identification of TOR signaling complexes: more TORC for the cell growth engine.

Cell. 2002 Oct 4;111(1):9-12. doi: 10.1016/s0092-8674(02)01009-7.

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

EMBO J. 1995 Dec 1;14(23):5892-907. doi: 10.1002/j.1460-2075.1995.tb00277.x.

High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target.

Protein Sci. 1994 Dec;3(12):2435-46. doi: 10.1002/pro.5560031227.

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Functional mapping of yeast genomes by saturated transposition.

Elife. 2017 May 8;6:e23570. doi: 10.7554/eLife.23570.

Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.

Metabolomics (Los Angel). 2016;6(3). doi: 10.4172/2153-0769.1000183. Epub 2016 Aug 20.

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.

Aging Cell. 2014 Apr;13(2):311-9. doi: 10.1111/acel.12175. Epub 2013 Dec 5.

Functional and genetic interactions of TOR in the budding yeast Saccharomyces cerevisiae with myosin type II-deficiency (myo1Δ).

BMC Cell Biol. 2012 May 30;13:13. doi: 10.1186/1471-2121-13-13.

Target of rapamycin (TOR) in nutrient signaling and growth control.

Genetics. 2011 Dec;189(4):1177-201. doi: 10.1534/genetics.111.133363.

mTOR signaling in cancer cell motility and tumor metastasis.

Crit Rev Eukaryot Gene Expr. 2010;20(1):1-16. doi: 10.1615/critreveukargeneexpr.v20.i1.10.

Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.

Mol Cell Biol. 1999 Jun;19(6):4101-12. doi: 10.1128/MCB.19.6.4101.

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

EMBO J. 1999 May 17;18(10):2782-92. doi: 10.1093/emboj/18.10.2782.

Cell wall integrity modulates RHO1 activity via the exchange factor ROM2.

EMBO J. 1998 Apr 15;17(8):2235-45. doi: 10.1093/emboj/17.8.2235.

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

Genes Dev. 1998 Feb 15;12(4):502-13. doi: 10.1101/gad.12.4.502.

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The TOR signalling pathway and growth control in yeast.

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